- Benedict Chumberbatch as Nicky Hard
- Malachi Barton as Young Nicky
- Amy Adams as Julia Hopper
- Ariana Greenblatt as Young Julia
- Mandy Moore as Elsa Owlweather
- Cedric the Entertainer as Stupid Flash
- Steve Martin as Professor Mayhem
- Adam DeVine as Chief Pogo Stick
- Tina Fey as Francisca Mayhem
- Sia as Alicorn
- Julia Roberts as Bixie Hard
- Ken Jeong as Stanley Hard
- Jamie Foxx as Buffa Loo
- J.P. Manoux as Mayor Pureheart
- David Gallagher as Frank Fastwalker
- Fred Tatasciore as Dash Smoothtalk
- Grey DeLisle as Pearl
- Catherine O'Hara as Flora Leopardis
- Simon Lipkin as Patrick Pandridge
- Richard Overall as Fiddly Orange
- Katherine Dillon as Young Fiddly
- Tara Strong as Puppy and Angry Pony
- Kath Soucie as Puppy’s Mom
- Bronson Pinchot as Lynx
- It was the second Shires Animation Studios film to show "Shires Presents" credit since Chris and Dhris Rescue Rangers.
- The fourth Shires Animation Studios film to use the short 2011 Shires closing logo, since Chris and Dhris Rescue Rangers.
- This is the tenth Shires Animation Studios feature to have the "Created and Produced at Shires Animation Studios, www.shires.com" credit at the end.
- This is the eighth Shires movie to have the title card appear both at the start and at the end (before the credits).
- Do Anything - Alicorn
- Do Anything (Reprise) - Alicorn
Zoomania was originally scheduled to be released on March 26, 2021, but due to the 2019–2020 coronavirus pandemic, it was pushed back to July 23, 2021.
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