- Ben Stiller as Wicked Ryan
- Kyla Rae Kowalewski as Virginia von Sharpsteen
- Dan Russell as Fix-It Fred
- Whoopi Goldberg as Janet Collingwood
- Jeffrey Tambor as King Callaghan
- Brad Garrett as Sour Bob
- Patrick Stewart as General Henderson
- Emily Tennant as Polly the Girl
- Wallace Shawn as Ted the Chilhahua
- Miley Cyrus as Thelma Maidstone
- Simon Pegg as Manchester
- Ed O'Neill as Mr. Smith Lapwick
- Kevin Michael Richardson as Winchell
- Corey Burton as Davis
- It was the first Shires Animation Studios film to show "Shires Presents" credit since Chris and Dhris Rescue Rangers.
- The first Shires Animation Studios film to use the short 2011 Shires closing logo, since Chris and Dhris Rescue Rangers.
- This is the ninth Shires Animation Studios feature to have the "Created and Produced at Shires Animation Studios, www.shires.com" credit at the end.
- This is the seventh Shires movie to have the title card appear both at the start and at the end (before the credits).
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