- Ben Stiller as Wicked Ryan
- Kyla Rae Kowalewski as Virginia von Sharpsteen
- Dan Russell as Fix-It Fred
- Whoopi Goldberg as Janet Collingwood
- Jeffrey Tambor as King Callaghan
- Brad Garrett as Sour Bob
- Patrick Stewart as General Henderson
- Emily Tennant as Polly Pocket
- Wallace Shawn as Ted the Chilhahua
- Miley Cyrus as Thelma Maidstone
- Simon Pegg as Manchester
- Candi Milo as Curly (Replacing Eartha Kitt) and Pam the Destroyer (Replacing June Foray)
- Ed O'Neill as Mr. Smith Lapwick
- Kevin Michael Richardson as Winchell
- Corey Burton as Davis
- Catherine Disher as Belle
- Jennifer Saunders as Snow White
- Susie Dent as Cinderella
- Rachel Riley as Ariel
- Joanna Lumley as Aurora
- Julia Sawalha as Jasmine
- Lena Headey as Pocahontas
- Jane Horrocks as Mulan
- Carol Vorderman as Tiana
- Reese Witherspoon as Rapunzel
- Scarlett Johansson as Merida
- Boris Johnson as himself
- Donald Trump as himself
- John Malkovich as Hero
- Shuya Chang as Hero Girl
- Marko Zaror as Evil Guy
- Duke Cutler as Humphrey
- Brian Froud as DemiDevimon
- Derek Stephen Prince as Impmon
- Sarah-Nicole Robles as Luz Noceda (uncredited)
- Wendie Malick as Eda (uncredited)
- Alex Hirsch as King (uncredited)
- Steve Blum as Saturn the Dog-Cat (uncredited)
- Amber Clark as Maggie Simpson (uncredited)
- Drew Nelson as Duncan
- Scott McCord as Owen
- Deven Mack as Chef Hatchet
- Emilie-Claire Barlow as Courtney
- Katie Crown as Izzy
- Cory Doran as Noah
- Sarah Gadon as Beth
- Christian Potenza as Jude Lizowski
- Kristin Fairlie as Bridgette
- Lilly Bartlam as Gwen
- Bahia Watson as Leshawna
- Darren Frost as Harold
- Wyatt White as Cody
- Evany Rosen as MacArthur
- Writing's on the Wall - Sam Smith
- Fireworks - Katy Perry
- Green Light Ride - Crush 40
- It was the first Shires Animation Studios film to show "Shires Presents" credit since Chris and Dhris Rescue Rangers.
- The first Shires Animation Studios film to use the short 2011 Shires closing logo, since Chris and Dhris Rescue Rangers.
- This is the ninth Shires Animation Studios feature to have the "Created and Produced at Shires Animation Studios, www.shires.com" credit at the end.
- This is the seventh Shires movie to have the title card appear both at the start and at the end (before the credits).
- This is the second Shires+ original movie to get a home video release.
- The first Shires animated film that was both produced and released during the COVID-19 pandemic.
- The film was animated entirely at home.
- The first Shires Animation Studios film to include the 2019 MPA logo in the end credits.
- This is the first full-length Shires Animation Studios film to skip the theaters and being instead released exclusively on Shires+.
- This is the first Shires Animation Studios film that was originally going to be released in theaters, but delayed to Shires+.
- Wicked Ryan was originally scheduled to be released on December 25, 2020, but due to the 2019–2020 coronavirus pandemic, it was pushed back to March 26, 2021.
- The animation is produced by Presto Animation System and Marionette.
- Although this movie was rated PG-13 in the United States, it was rated 12 in the United Kingdom.
Home video releases:
- Wicked Ryan 2
- Wicked Ryan 2