When TV Show Villain Wicked Ryan is tired of being wicked, He teams up with An Unimportant Background Character from Another Show named Virginia to defeat the show’s main villain, King Callaghan.
- Ben Stiller as Wicked Ryan
- Kyla Rae Kowalewski as Virginia von Sharpsteen
- Dan Russell as Fix-It Fred
- Whoopi Goldberg as Janet Collingwood
- Jeffrey Tambor as King Callaghan
- Brad Garrett as Sour Bob
- Patrick Stewart as General Henderson
- Emily Tennant as Polly the Girl
- Wallace Shawn as Ted the Chilhahua
- Miley Cyrus as Thelma Maidstone
- Simon Pegg as Manchester
- Ed O'Neill as Mr. Smith Lapwick
- Kevin Michael Richardson as Winchell
- Corey Burton as Davis
- This is the first Shires movie to have the title card appear both at the start and at the end (before the credits).
- Ted the Chihuahua from Paul and Company makes a cameo appearance in the movie.
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