Vampire Movie is a parody film which spoof vampire films and shows such as Buffy the Vampire Slayer, Van Helsing, From Dusk Till Dawn, Dracula Movies (mostly Bram Stoker's Dracula), The Lost Boys, Fright Night, Interview with a Vampire and others. It was directed by Keenen Ivory Wayans.
A teenager named Muffy Jan Helsing who is a schoolgirl by day and vampire hunter by night decided to hunt vampiric versions of dead celebrities such as Michael Jackson, Heather O'Rouke, Tupac, and the like, but she has to team up with her friends, Charlie Brewington and Millie Roseberg.
- AJ Michalka as Muffy Jan Helsing, a vampire hunter and a teenage schoolgirl who is currently at Bram Stoker High. She slays vampires.
- Cole Sprouse as Charlie Brewington, Muffy's boyfriend and a talkative wise-cracking boy.
- Brec Bassinger as Millie Roseberg, a witchy nerd who is Charlie's friend.
- Tom Holland as Jared Dandruff, a parody of Jerry Dandridge and a vampire whose dad is the head vampire.
- Christopher Walken as Count Vladimir "Dracula" Dandruff, the count and main antagonist
- Piper Curda as Tanya Wong, a teenage girl at Bram Stoker high and Muffy's friend
- Dove Cameron as Dolores Cruise, a popular teenage girl and parody of Regina George and Cordelia Chase
- Ben Schwartz as Aaron, a janitor who happens to be a vampire
- Kyle Red Silverstein as Young Aaron
- Kristen Bell as Isabel, the principal
- Veronica Dunne as young Isabel
- Eden Sher as Marisol Brown, a ditzy Fangirl of Buffy the Vampire Slayer who turns out to be a vampire
- Abby Elliot as Tara, a student at Bram Stoker High and a responsible one
- Sarah Michelle Gellar as Buffy Summers
- Tori Kelly as Marla, a parody of Darla from Buffyverse. She drained out the blood of her first victim, Todd.
- Charlie Heaton as Todd Chalk
- Dakota Blue Richards as Nina, a student at Bram Stoker High and a bully victim
- Cassie Scerbo as Lea, a student at Bram Stoker High and a smart one
- Grace Jones as Katrina, a character from Vamp
- Estelle as Korina, Katrina's long lost stepcousin
- Juliet Landau as Drusilla
- James Marsters as Spike
- Michael Cera as Billy Grundown, a student at Bram Stoker High and a jock
- Selena Gomez as Darla, a student at Bram Stoker High and a cheerleader
- Marlon Wayans as Shorty, a janitor at Bram Stoker High
- Robert Patterson as Edward Cullen, the Vampire that Muffy staked
- Kristen Stewart as Bella Swan
- All Dracula films - Count Dracula appears
- Buffy the Vampire Slayer - Buffy appears in the movie and meets Muffy.
- The Lost Boys - David appears as a cameo
- Lair of the White Worm - Marla says "I don't wanna go Lair of the White Worm on you" to Todd after draining the blood and life force out of him
- Vamp (1986) -
- Bordello of Blood -
- From Dusk Till Dawn -
- Blade -
- Fright Night - Jared Dandruff appears
- Treehouse of Horror IV - Vampires float inside Muffy's window as Jared flies out of the window to attack Muffy
- The Munsters - Marla wears a Lily Munster dress
- Clueless - Muffy says "As if" at a vampire