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Ultimate Spider-Man 2 is the 2016 sequel to the 2014 film Spectacular Spider-Man, which was released outside of North America as Ultimate Spider-Man. It was followed by Ultimate Spider-Man 3

Plot

Two years after Norman Osborn's death, Peter Parker (Nick Palatas), secretly the superhero Spider-Man, finds himself struggling to balance his superhero responsibilities with those of his personal and professional lives. He has become estranged from both love interest Mary Jane Watson (Miley Cyrus) and best friend Harry Osborn (Robbie Amell), and discovers that his Aunt May (Alexondra Lee) is facing eviction. Additionally, he has found himself suffering temporary, but recurring losses of his powers, often in life-threatening situations.

Harry, now head of Oscorp's genetic and scientific research division, is sponsoring a fusion power project by nuclear scientist Otto Octavius (Erik von Detten), who befriends and mentors Peter. While handling hazardous materials, Octavius wears a harness of powerful robotic tentacle arms with artificial intelligence. During a public demonstration that Peter and Harry attend, a power spike causes the fusion reactor to destabilize. Octavius refuses to shut down the reactor, which goes critical, killing his wife (Mandy Moore), fusing the harness to his spine, and destroying the inhibitor chip blocking the arms from his nervous system. Peter quickly suits up as Spider-Man and shuts the experiment down, destroying it in the process.

At a hospital, doctors prepare to surgically remove Octavius' harness. However, with the inhibitor chip destroyed, the arms have developed sentience and attack them. Upon regaining consciousness and seeing the carnage, Octavius escapes and takes refuge at a harbor. Becoming increasingly influenced by the arms' AI, he robs a bank to fund a second experiment. Peter and May coincidentally are there, and Octavius takes May hostage. Spider-Man rescues her, but Octavius flees with stolen money. The Daily Bugle subsequently dubs the scientist Doctor Octopus.

Mary Jane becomes engaged to astronaut John Jameson (Taylor Lautner), son of Bugle editor J. Jonah Jameson (J.K. Simmons). Peter suffers an emotional breakdown over his inability to balance his life and loses his powers. He abandons his Spider-Man identity, returns to his normal life, and attempts to reconcile with Mary Jane. A garbageman brings Peter's Spider-Man costume to Jameson, who takes credit for driving Spider-Man into hiding. Peter tells May the truth behind his Uncle Ben's death and how he is responsible. May forgives him, but the rise in New York City crime rates worries Peter.

Requiring the isotope tritium to fuel his reactor, Octavius visits Harry to demand it. Harry agrees in exchange for Spider-Man, whom he believes is responsible for Norman's death. He tells Octavius to seek Peter, who Harry believes is friends with Spider-Man, but tells Octavius not to harm him. Octavius locates Peter, tells him to find Spider-Man, and captures Mary Jane. Her endangerment leads to Peter's powers returning. As Jameson admits that he was wrong about Spider-Man, Peter steals his costume back from the Bugle and goes after Octavius.

As Spider-Man battles Octavius, they fall onto a New York City Subway train. Octavius sabotages the controls and leaves Spider-Man to save the passengers, which he does at a great physical toll. When he faints from exhaustion, the grateful passengers save him from falling and bring him into the train, seeing his unmasked face but promising to keep their knowledge hidden. In vain, they try to protect him when Octavius returns to capture Spider-Man, whom Octavius delivers to Harry.

After giving Octavius the tritium, Harry prepares to kill Spider-Man, only to be shocked to see Peter under the mask. Peter convinces Harry to direct him to Octavius' lair, as bigger things are at stake. As Spider-Man arrives at the doctor's waterfront laboratory and attempts to rescue Mary Jane discreetly, Octavius discovers him, and they battle as the nuclear reaction swells. Spider-Man ultimately subdues Octavius, reveals his identity, and persuades Octavius to let his dream go for the greater good. Octavius commands the tentacles to obey him, and gives his life to destroy the experiment. Mary Jane sees Peter's true identity and feelings, which he says is why they cannot be together. Spider-Man returns Mary Jane to John, and leaves.

Harry is visited by a vision of his father in a mirror, pleading for Harry to avenge his death. Refusing, Harry shatters the mirror, inadvertently revealing a secret room containing prototypes of the Green Goblin's equipment. On her wedding day, Mary Jane abandons John at the altar and runs to Peter's apartment. After they kiss, they hear police sirens, and Mary Jane encourages him to go help as Spider-Man.

Cast and Characters

Nick Palatas as Peter Parker/Spider-Man. A superhero, Columbia University physics student, and photographer for the Daily Bugle

Miley Cyrus as Mary Jane Watson. A friend Peter has loved since he was a child, yet he gave up the chance of being with her out of concern for her safety.

Robbie Amell as Harry Osborn. Oscorp's leader, Norman Osborn's son and Peter's best friend who holds Spider-Man responsible for his father's death.

Erik von Detten as Dr. Otto Octavius/Doc Ock. A scientist and Peter's role model who goes insane after his failure to create a self-sustaining fusion reaction. Octavius is bonded with his handling equipment, four artificially intelligent mechanical tentacles. 

Alexondra Lee as Aunt May Parker. Peter's aunt. Ben Parker's widow and Peter's aunt.

J.K. Simmons as J. Jonah Jameson.

Mandy Moore as Rosalie "Rosie" Octavius. Otto's wife and assistant.

Taylor Lautner as John Jameson. Mr. Jameson's son.

Owen Wilson as Dr. Curt Conners. One of Peter's college physics professors and a colleague of Octavius.

Jennifer Love Hewitt as Betty Brant

Jeremy London as Mr. Ditkovitch. Peter's landlord.

Kate Melton as Ursula Ditkovitch. Mr. Ditkovitch's daughter.

James Franco as Norman Osborn/Green Goblin

Tobey Maguire as Uncle Ben Parker (seen in flashbacks)

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