Space Mouse is a 2008 American family adventure live-action film directed by Matt Lopez, was produced by Regency Enterprises and was distributed by 20th Century Fox and was released on April 4, 2008.


  • Sean Astin as Space Mouse, a house mouse from Rodentia.
  • Jason Biggs as Mr. Squiggles, Space Mouse's father.
  • Kelly Hu as Jilly, Space Mouse's mother.
  • Novie Edwards as Katie, Space Mouse's owner.
  • Jason Lee as Splinter, a tiger who is Space Mouse's arch-nemesis and antagonist of the film.
  • Kate McKinnon as Nellie, a cockatoo one of Space Mouse's friends.
  • Hynden Walch as Misty, a European hedgehog one of Space Mouse's friends.
  • Jacqueline Pillon as Brainy, a European rabbit one of Space Mouse's friends.
  • Craig T. Nelson as Seamus, a German Shepherd Dog who is Space Mouse's best friend.
  • Owen Wilson as Joey, a North American raccoon one of Space Mouse's friends.
  • Mae Whitman as Joy, a house mouse who is Space Mouse's love interest.
  • Sia as Ivy, a White-Tailed Deer who is Space Mouse's second best friend.
  • Samuel L. Jackson as Sultan, an African spurred tortoise one of Space Mouse's friends.
  • Andrew Kishino as Leonard, an African wild dog who the secondary antagonist of the film.
  • Tom Conway as The Narrator.


  1. Don't Go Breaking My Heart – Elton John
  2. You're My Best Friend – Queen
  3. Happy Together – The Turtles
  4. Hotel California – Eagles
  5. Bad Day – Daniel Powter
  6. What a Wonderful World – Louis Armstrong
  7. Beyond the Sea – Robbie Williams


  • Love Song by Sara Bareilles is played in the trailer.
  • Beyond the Sea by Robbie Williams is played in the ending credits of the movie.
  • Space Mouse first aired on Cartoon Network on October 13, 2010.
  • Space Mouse first aired on Nickelodeon on May 14, 2013, on September 17, 2014 and on June 14, 2019.
Community content is available under CC-BY-SA unless otherwise noted.