An upcoming 2019 film that is exclusive to Shires+.
- Tessa Thompson as the Narrator
- Jim Cummings as Scamper
- Sarah Hyland as Lassie
- Janelle Monae as Paige
- Grey DeLisle as Florence (replacement of Sultanna and Siam)
- Sam Elliot as Thomas
- Yvette Nicole Brown as Jelly (Female Jack)
- Parvesh Cheena as Tucker
- Eric Bauza as Buzzy the Beaver
- Kath Soucie and Tara Strong as The Nurse Dogs
- Roger Craig Smith as Pongo
- Stephen Root as Geoffrey
- Fred Armisen as Weiner
- Keegan Michael-Key as Big Boris
- Jordan Peele as Bulldog
- Jerry Hausner (archive recording) as Cuckoo Bird
- Dee Bradley Baker as Laughing Hyena and The Alligator
Live Action People
- Kiersey Clemons as Mrs. Schieb
- Thomas Mann as Mr. Schieb
- Jamie Lee Curtis as Aunt Sally
- John Goodman as Thompson
- Timothy West as Johnny
- James Caan as The Dogcatcher
- Arturo Castro as The Policeman
- Main Title (Beautiful Night)/It Came Upon a Midnight Clear - Chorus and Milton Charles
- What is Love - Lassie
- La La Low - Mrs. Schieb
- My Favorite Things - Scamper and Florence
- Off the Leach - Scamper
- Beautiful Night - Thompson and Johnny, later Chorus
- As Time Goes By - Paige
- All Bows on Me - Florence
- It Came Upon a Midnight Clear (Reprise) - Chorus
- In the original, The Nurse Dogs are male. In the remake, they are female.
- Jack is replaced by a female named Jelly.
- Sultanna and Siam are replaced by Florence the Poodle for the villain, which unlike them, Florence gets more screen time.
- Jamie Lee Curtis returns to Shires after doing the voice of Ava from the Shires Channel Original Franchise, Beverly Hills Greyhound.