Revenge on Lauren Malloy take place after Scream: Cami Watson's Past. Lauren escape psychiatric hospital, with wear blue shirt, white tank top, coat, black short and shoes after girls in psychiatric hospital get revenge on Lauren for killing people. One of the girls, Imogen Clooney wanted to kill Lauren for killing her brother, Jerry. Lauren is blackmail by Shaun who is still alive. Lauren need somebody to help her.
The 7 girls in psychiatric hospital who get a revenge on Lauren is Imogen Clooney, Sienna Hanson, Keira Clooney, Danielle Campbell, Katie Peterson, Jenna Collins and Mandy James
- Georgie Henley as Lauren Malloy
- Mark Wahlberg as Shaun Webber
- Imogen Poots as Imogen Clooney
- Timothy Dalton as Captain Bruce Hanson
- Blake Lively as Sienna Hanson/Bruce's daughter and Imogen's friend
- Emily Browning as Keira Clooney/Imogen's sister
- Teresa Palmer as Danielle Campbell
- Maggie Grace as Katie Peterson
- Zooey Deschanel as Jenna Collins
- Lily Collins as Mandy James/Sara's sister
- Katherine Heigl as Samantha Hanson/Bruce's daughter and Sienna's sister
- Michelle Pfeiffer as Detective Elizabeth Stephens/The mother of the dead Kate Stephens
- Elle Fanning as Kate Stephens/Elizabeth's daughter who was found dead by Lauren in 9 years ago
Lauren meet Sienna's father, Captain Bruce Hanson
- (Lauren cough)
- Lauren: So cold...
- Lauren: I'll never be alive in this weather.
- (Somebody hit Lauren with the bottle and Lauren scream)
- (Lauren groan)
- (Black screen)
- Lauren (closing her eye): No, no, no, NO!!!!
- (Lauren scream and wake)
- Lauren: (groan) My head.....
- (Lauren walk)
- Lauren (saw a kid is Sienna in the photo): Sienna?
- Bruce: Sienna is my daughter.
- Lauren (holding the gun): Are you Sienna's father?
- Bruce: Yes.