- Logan Lerman as Jack Tatum
- Alison Stoner as Bridget Kidman
- Jack Reynor as Steve Leonard
- Zoey Deutch as Isabelle Patto
- TBA as Dr. Elias Wharton, an astronomer who spotted the Predator's ship on his telescope.
- Emma Stone as Olivia Vincent, Dr. Wharton's assistant.
- Nikolai Coster-Waldau as Simon Weyland, the CEO of Weyland Industries.
- Arnold Schwartznegger as Alan "Dutch" Schaffer, a former U.S. Special Forces major who is the only survivor of the 1987 Guatemala mission. Schwartznegger reprises his role from the 1987 action film Predator.
- TBA as Sheriff Jacob Halbert, the town sheriff.
- TBA as Lieutenant General Theodore Giddings, USA.
- Jason Statham as Major Roger Freeman, USA.
- James Badge Dale as Master Sergeant William Mars, USA.
- Kevin Hart as Deputy Patrick Sachs, the town deputy.
- TBA as Charile Tatum, Jack's father.
- TBA as Vic Miller
- TBA as Principal Oswald Jones
- TBA as Mr. Laurence Dallas