Plot
Main Characters
- Matthew Mouse (voiced by Eric Bauza)
- Douglas Duck (voiced by Chris Sanders)
- Boofy (voiced by Bill Fagerbakke)
- Greedy Cat (voiced by Phil LaMarr)
- Pippin the Bug King (voiced by Jim Cummings)
Recurring Characters
- The Cleaner-uppers
- Michelle Mouse (voiced by Bill Fagerbakke)
- Doris Duck (voiced by Kath Soucie)
- Kylie Koala (voiced by Tara Strong)
- Dluto (sounds provided by Mel Blanc; archive audio)
- Twigaro (sounds provided by Dee Bradley Baker)
- Chris and Dhris (voiced by Keegan-Michael Key and Jordan Peele)
- Hegen Horse (voiced by Grey DeLisle)
- Jack the Junkyard Jaguar (voiced by Fred Armsien)
- Lackett Bassett (voiced by Roger Craig Smith)
Friends Around the World
- Felix Fox (voiced by Phil LaMarr)
- Mr. Eagle (voiced by John DiMaggio)
- Skipper the Fly (voiced by Frank Welker)
- Stinky (voiced by Dee Bradley Baker)
- Clammy (voiced by Frank Welker)
- Dr. Benson Honeydew (voiced by Frank Welker)
- Baker (voiced by Dee Bradley Baker)
- Tinkerbell (sounds provided by Dwayne Hill)
- Summer Lion (voiced by Kristen Wiig)
