Lauren Malloy come back to New York takes place after Scream: Frank Nightingale's Stalker. Hayley, Brooke and Lloyd went on vacation in New York. Hayley found out Lauren return to New York. Hayley need Leon Brooks's help who save her by Lauren when Hayley try robbed a bank, to stop Lauren to kill the people.
- Georgie Henley as Hayley McDonald/Lauren Malloy
- Mark Wahlberg as Detective Leon Brooks
- Natasha Henstridge as Chloe Brooks
- J.C Brandy as Brooke McDonald
- Chance Crawford as Lloyd McDonald
- Isabella Acres as Rosie Brooks/Leon and Chloe's daughter and Katie's sister
- Caitlin Carmichael as Katie Brooks/Leon and Chloe's daughter and Rosie's sister