Henry and O'Brown are one of two secondary antagonists in the animated television series, Goosehollow. They are the corrupt owners of the cheese factory who serve as second in command to Madam.
Madam, Henry and O'Brown were first seen in the factory when Big Fat Man goes to work with Jake. They finally fires Jake because he was late, while Henry convinces Big Fat Man and brands him as a troublemaker and so Madam sends Henry and O'Brown to keep an eye on Big Fat Man.
They were laughing with Madam over how they pay him to violently beat the immigrants. Scuttlebutt is revealed to be on the trio's payroll and tells the trio of a treasure map because he overheard Fievel and Tony discussing the train tunnel. Later, a riot goes on because of how Grasping, Toplofty, and O'Bloat force the mouse workers in the cheese factory work 3 times harder for the same pay.
Eventually, Jake discover a Lenape tribe of monsters below a tunnel in NYC. The factory owners had caught wind of this and were immediately panicked. However, they come up with an idea: portray the humans as enemies of both the workers and themselves to trick the workers into forgetting about work issues. They making the workers their slaves so they can rule like tyrants.
Henry and O'Brown stir up fear in the workers about the Native Americans, leading to a demonstration. Big Fat Man is almost executed, while Jake announces that the monsters are unfits for the salvation of humankind and the factory owners were the enemies, Henry was furious and blames Madam for making everyone hate them (presumably for lying that Big Fat Man was a foreigner and not one of them, when in reality they were all foreigners) and O'Brown seems to be scared as he thinks that they are humans who is going to invade them.
Off-screen, Jake kills Henry and O'Brown by cutting his heads with a spear and mounted them on the fireplace.