Dr. Mario is a playable character in the fighting video game, M.U.G.E.N Trilogy. He is a clone of Mario and was confirmed on February 1, 2015 along with the other characters from Super Smash Bros. Melee. Charles Martinet (who also assumes the role for Mario, Luigi, Wario and Waluigi) provides the role for Dr. Mario in this fighting game, using the same voice clips as the regular Mario.
Dr. Mario is simply Mario in a doctor's uniform, fighting against multicolored Viruses by throwing variously-colored Megavitamins into position and lining them up four in a row. He originated in the 1990 NES/Game Boy game Dr. Mario. Almost all of Dr. Mario's appearances have been in his eponymous subseries of puzzle games, which has received entries on numerous Nintendo systems. The most recent installment is Dr. Mario: Miracle Cure for the Nintendo 3DS, which curates the majority of the content from throughout the series into one package including the remixed game mode starring his brother. Mario can also unlock and wear the Dr. Mario costume in Super Mario Maker from the Mystery Mushroom and Super Mario Odyssey from purchasing it in the in-game shop.
Some of Dr. Mario's aesthetics also differ from Mario's. Most noticeably, his forward smash discharges electricity, instead of producing a small burst of fire. In addition, Dr. Mario is less vocal and his animations are less energetic, depicting him as more serious and contemplative.
How to Unlock
Use Dr. Mario's Super Smash Bros. amiibo or scan Dr. Mario's AR Icon from the M.U.G.E.N Trilogy website.