- Ryan Potter as Takato Matsuki, the leader of the Tamers and an imaginative artist.
- Mackenyu as Henry Wong, a Tamer and the voice of reason of the group.
- Anya Taylor-Joy as Rika Norward, a tomboyish and headstrong but experience Tamer.
- Ryo Kase as Mitsuo Yamaki, the mysterious director of Hypnos who is tasked to apprehend any Digimon that appears in the Earth.
- Scott Adkins as Whalen Derek, a Hypnos field agent and the field leader of the Hypnos' black ops unit.
- Tao Okamoto as Riley Ohtori, a Hypnos agent and the chief technical operator.
- Keiko Kitagawa as Tally Onodera, a Hypnos agent and a systems operator.
- Kerris Dorsey as Jeri Kassidy, one of Takato's friends from school.
- Paul Giamatti as Lyle
- Lacey Chabert as Tracy
- Amanda Crew as Helen
- Adrian Sparks as Jude
- Christain Bale as Kyle Vale
- Kyle Richards as Annie
- Seth Meyers as Elroy Myers
- Alec Baldwin as Nicholas
- Lil Rel Howery as a comic book shop owner.
- Steve Blum voices Guilmon, Takato's Digimon partner.
- Javier Botet as Guilmon (motion-capture performance)
- Mona Marshell voices Terriermon, Henry's Digimon partner.
- Mari Devon voices Renamon, Rika's Digimon partner.
- Zoë Bell as Renamon (motion-capture performance)
- Michael Hollick as Clark
- Hank Azaria as Steven
- Adam DeVine as Paul Tinfoil
- Josh Zuckerman as Francis
- Aubrey Plaza as Morena
- Frank Bonsangue as Gregory
- Greg Berger as Adam Madison
- ??? minutes long.
- The film is rated PG-13 for action violence and language.
- The film is distributed by Universal Pictures and Legendary Pictures, while being produced by Saban Films and Toei Company.
Main Character Gallery
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