Cast:
- Will Ferrell as Christopher Rogers
- Toby Jones as Richard Butterworth
- Owen Wilson as Gas Smith Jr.
- Jennifer Aniston as Evelyn Rogers
- Sofia Garcia as Madeline Rogers
- Will Arnett as Hal Gayhound
- Jason Alexander as Policeman Body
- Will Smith as New Man Smith
- Chris Rock as Matthew Leonard
- Phil LaMarr as Cecil Howard
- Dane Boedigheimer as a taxi driver
- Lucas Cruiskank as a newspaper seller
- Jennifer Love Hewitt as Katherine Davis
- Sam Rockwell as Paul Hulett
- Jennifer Lopez as Joan MacManus
- Mark Hamill as Christopher Rogers's mother
- Nicole Kidman as Christopher Rogers's father
Voice Cast:
- Rob Paulsen as Elmo the Monster
- Jess Harnell as Tippy
- Kath Soucie as Kiara
- Tara Strong as Ringo
- Tom Kenny as Pipers
- Brian Blessed as Igor
- Roger Ashton-Griffiths as Mighty Condor
- Bill Farmer as Gopher
- Rory Kinnear as Willy Nilly Racoon
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