Black Widow is a playable character in Marvel: Civil War and Marvel: Age of Ultron.
Joining the pro-registration had cost Natasha her beloved Captain America. Until she was ready attempt reconciliation with Steve Rogers, she did her part to hunt down the remains of the pro-registration side.
Captain America sent Black Widow, an alternate Hawkeye and Deadpool to combat the Masters. She and Hawkeye were warned by Doctor Strange of an incoming threat to Earth.
Loki pursued Black Panther and Doctor Doom with a brainwashed Black Widow, Hawkeye and Spiderman.
Natasha Romanoff and Clint Barton learn that their daughter Kate, is a mutant.