- Jack McBrayer as Yoo Henson
- Wallace Shawn as Bee-Rex
- Chris Rock as Frank
- Cedric the Entertainer as Walden
- Lacey Chabert as Go Go Taito
- Kristen Wiig as Helen Lenny
- Owen Wilson as Taito Henson
- Liam Neeson as Richard Carlton
- Gilbert Gottfried as Harry Classified
- Charlie Adler as Alan Kenny
- Cheech Marin as Yummy
- Alan Oppenheimer as Police Officer
- John C. Reilly as Humphrey
- Dick Van Dyke as Frank's Dad
- Angela Lansbury as Aunt Case
- Emily Blunt as Angie
- Max Charles as Humphrey
- Brian Froud as DemiDevimon
- Derek Stephen Prince as Impmon
- Laura Summer as Patamon
- This is the fifth Shires Animation Studios film to feature the full 2011 Shires opening logo as a closing logo.
- This is the seventh Shires Animation Studios feature to have the "Created and Produced at Shires Animation Studios, www.shires.com" credit at the end.
- The fifth film with the Shires logo under the movie title.
- This is the third Shires animated feature to show only the studio logos in the beginning, and the title card and credits only appear at the end.
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